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Home About AOTI History Market Opportunity Press Room Management Scientific Advisory Products Re-Usable Single Use Wound Types Arterial & Diabetic Ulcers Venous Ulcers Pressure Ulcers Clinical Evidence Clinical Studies Economic Value Guidelines Associations Contact Us	Clinical Studies, Case Series & Abstracts AOTI is committed to providing the strongest scientific evidence as to the therapeutic benefits of our unique two2™ therapy. The following table and links detail the already extensive published evidence as to the utility of Topical Wound Oxygen. Additionally, the company is sponsoring three separate Randomized Controlled Trials encompassing over 250 patients, that are specifically investigating the clinical outcomes and cost saving benefits of our therapy in both Diabetic and Venous ulcer patients.  These studies are either ongoing or awaiting publication in leading journals. Author Journal Study Type No. of Patients Ulcer Type Outcome W. Tawfick, S. Sultan European Journal of Vascular and Endovascular Surgery Parallel study 83 Venous 90% Healed Sultan S et al Irish Journal of Medical Science Parallel study 60 Venous 90% Healing Dutton L et al Canada Wound Care Society Mtg. Case Study 1 Diabetic Effective in healing difficult wounds Kallianen LK et al Pathophysiology Case series 32 Mixed 75% closure rate. No side effects Edsberg LE et al Ostomy and Wound Management Parallel Randomized study 8 Pressure Healing of all wounds Edsberg LE et al Ostomy and Wound Management Case report 1 Diabetic Healing of wounds Landau Z et al Yale Journal Biology & Medicine Prospective open study 100 Diabetic 81% Healing Heng MC et al Ostomy and Wound Management Prospective randomized study 40 Pressure 90% closure rate Heng MC et al Ostomy and Wound Management Prospective Study 15 Pressure Overall improvement in ulcer size over time Landau Z et al Arch Orthopedic Trauma Surgery Prospective study 50 Diabetic 86% closure rate Upson AV Physical Therapy Case series 2 Arterial Positive experience Heng MC et al American Journal Dermatopatho. Case series 6 Pressure Some clinical improvement Ignacio DR et al Journal American Podiatry Asso. Case series 15 Mixed 73% healing rate Heng MC Australian NZ Journal of Medicine Case report 2 Diabetic Good healing in both cases Heng MC et al Archives Dermatology Prospective non- randomized study 6 Necrotic Pressure 100% healing in TOT group Heng MC Australian Journal Dermatology Case report 1 Diabetic Granulation of deep ulcer Diamond E et al Journal American Podiatry Assoc Case series 11 Mixed 100% healing Olejniezak S Medical Times Meta Analysis Self Control 174 Mixed Very Effective/ Favorable Results Fischer BH Journal Dermatological Surgery Case series 30 Mixed Overall positive results Fischer BH Lancet Case series 52 Mixed Positive results The following clinical studies, case series and abstracts detail the safety, efficacy and effectiveness of Topical Hyperbaric Oxygen (two2™) therapy in treating and resolving a variety of ulcers Hyperbaric and Topical Wound Oxygen: A Comparatave Study (click to read) The use of Topical Wound Oxygen (two2™) on Complex Recalcitrant Wounds in Multi-Morbid Patients (click to read) Topical Wound Oxygen (two2™) used with Standard best Practice Wound Care on Recalcitrant Lower Extremity Ulcers (click to read) Treatment of a Chronic Wound Patent with Takayasu's Arteritis with Topical Wound Oxygen (two2™) in an Out-Patient Setting in Latvia (click to read) First Experience in the Treatment of Chronic Venous Ulcers with Topical Wound Oxygen (two2™) in an Out-Patient Setting in Latvia (click to read) Treatment of a Chronic Stage IV Pressure Ulcer using Topical Wound Oxygen (two2™) (click to read) Therapy of a Septic Forefoot Phlegmone with Topical Wound Oxygen (two2™) in an Intensive Care Setting (click to read) Limb Salvage with Topical Wound Oxygen (two2™) – Two Cases of Complex Wounds in Multimorbid Patients and Imminent Major Amputation (click to read) A Randomized Controlled Trial to Evaluate Different Treatment Regimes with Topical Wound Oxygen (two2™) on Chronic Wounds (click to read) Topical Wound Oxygen (two2™) in Two Cases With Pressure Ulcers in Finland (click to read) Topical Wound Oxygen (two2™) Therapy in the Treatment of Severe Diabetic Foot Ulcers: A Prospective Controlled Study (click to read) Treatment of a Chronic Stage IV Pressure Ulcer using Topical Wound Oxygen (two2™) Therapy (click to read) Cost-Effectiveness of Localized Topical Oxygen vs. Advanced Wound Care in Chronic Wounds (click to read) Topical Wound Oxygen Therapy in the Treatment of Severe Diabetic Foot Ulcers: A Prospective Cohort Study (click to read) Does Topical Wound Oxygen (TWO2) Offer an Improved Outcome Over Conventional Compression Dressings (CCD) in the Management of Refractory Venous Ulcers (RVU)? A Parallel Observational Comparative Study (click to read abstract) Topical Wound Oxygen (two2™) Versus Conventional Compression Dressings in the Management of Refractory Non-healing Venous Ulcers; A Parallel Observational Pivotal Study, Tawfick & Sultan, IJMS, May 2007 (click to read abstract) Therapeutic value of hyperbaric oxygen in lower extremity ulcerations, Rossi, IJMS, May 2007 (click to read abstract) Topical Oxygen alters angiogenesis-related growth factor expression in chronic diabetic foot ulcers, Scott, IJMS, May 2007 (click to read abstract) Topical Hyperbaric Oxygen Therapy (THOT): Design concept to Market Product, Loori, IJMS, May 2007 (click to read abstract) Canada TWO Case Series - TOPICAL HYPERBARIC OXYGEN THERAPY: A CASE STUDY, Dutton, 2006 (click to read abstract) Sacral unit Case Study, Edsberg, Ostomy Wound Management, 2006 (click to read abstract) TPOT and Electrical Stim: Exploring Potential Synergy. Edsberg, Ostomy Wound Management, April 2003 (click to read abstract) TPOT Stimulate Growth Factors, Scott, Oct 2005 (click to read abstract) THOT for Pressure Sores and Ulcers, Fischer, Lancet, Aug 1969 (click to read abstract) Treatment of leg Ulcers with THOT, Fischer, Jnl Derm Surg, Oct 1975 (click to read abstract) Effects of Hyperbaric Oxygen on Lower Extremity Ulcers, Diamond, Jnl American Podiatry Assc, Apr 1982 (click to read abstract) Topical Hyperbaric Oxygen Therapy For Lower-Extremity Wound Care; An Overview, Rossi, Podiatry Management, Nov 1997 (click to read abstract) THOT for Recalcitant Wounds, Upson.Physical Therapy, Sep 1986 (click to read abstract) Reducing Epibole Using TPOT, Edsberg, Ostomy Wound Care, Apr 2002 (click to read abstract) Human Bite Infections and TPOT, Lehman, Infections in Surgery, Jun 1985 (click to read abstract) Angiogenesis in Necrotiv Ulcers with Topical O2, Heng, Ostomy Wound Management, Sep 2000 (click to read abstract) Effect of Continuous Topical O2, Kaufman, Journal of Trauma, Sep 1983 (click to read abstract) Revisiting Role of O2 In Wound Healing, Gordillo, AM J Surgery, Sep 2003.doc (click to read abstract) THOT and Laser, Landoz, Am Orth Trauma Surg, Jan 1998 (click to read abstract) THOT for Leg Ulcers, Ignacio, Jnl Am Podiatric Asc, Apr 1985 (click to read abstract) Topical O2 as an adjunct to wound healing, Kallianlnen, Pathophysiology, Nov 2002 (click to read abstract) Topical O2 For Problem Skin Wounds, Heng, Dermatol, Surg, 1993 (click to read abstract) Topical O2 in Burns, Kaufman (click to read abstract) Topical O2 Promotes Ulcer Healing, Olejanack, Medical Times, Dec 1976 (click to read abstract) Treatment of leg Ulcers with THOT, Fischer, Jnl Derm Surg, Oct 1975 (click to read abstract) Enh Healing and Cost Eff Heng Ostomy Wound Care Mar 2000 (click to read abstract)