History
Market Opportunity
Press Room
Management
Scientific Advisory
Re-Usable
Single Use
Sequal
Maxtec
Arterial &
Diabetic Ulcers
Venous Ulcers
Pressure Ulcers
Clinical Evidence
Economic Value
Guidelines
Conferences
Associations
Clinical Evidence
Clinical Evidence
AOTI is committed to providing the strongest scientific evidence as to the therapeutic benefits of our unique two2™ therapy. The following table and links detail the already extensive published evidence as to the utility of Topical Wound Oxygen. Additionally, the company is sponsoring three separate Randomized Controlled Trials encompassing over 250 patients, that are specifically investigating the clinical outcomes and cost saving benefits of our therapy in both Diabetic and Venous ulcer patients.  These studies are either ongoing or awaiting publication in leading journals.
Author
Journal
Study Type
No. of Patients
Ulcer Type
Outcome
W. Tawfick,
S. Sultan
European Journal of Vascular and Endovascular Surgery
Parallel study
83
Venous
90% Healed
Sultan S et al
Irish Journal of Medical Science
Parallel study
60
Venous
90% Healing
Dutton L et al
Canada Wound Care Society Mtg.
Case Study
1
Diabetic
Effective in healing difficult wounds
Kallianen LK et al
Pathophysiology
Case series
32
Mixed
75% closure rate. No side effects
Edsberg LE et al
Ostomy and Wound Management
Parallel Randomized study
8
Pressure
Healing of all wounds
Edsberg LE et al
Ostomy and Wound Management
Case report
1
Diabetic
Healing of wounds
Landau Z et al
Yale Journal Biology & Medicine
Prospective open study
100
Diabetic
81% Healing
Heng MC et al
Ostomy and Wound Management
Prospective randomized study
40
Pressure
90% closure rate
Heng MC et al
Ostomy and Wound Management
Prospective Study
15
Pressure
Overall improvement in ulcer size over time
Landau Z et al
Arch Orthopedic Trauma Surgery
Prospective study
50
Diabetic
86% closure rate
Upson AV
Physical Therapy
Case series
2
Arterial
Positive experience
Heng MC et al
American Journal Dermatopatho.
Case series
6
Pressure
Some clinical improvement
Ignacio DR et al
Journal American Podiatry Asso.
Case series
15
Mixed
73% healing rate
Heng MC
Australian NZ Journal of Medicine
Case report
2
Diabetic
Good healing in both cases
Heng MC et al
Archives Dermatology
Prospective non- randomized study
6
Necrotic Pressure
100% healing in TOT group
Heng MC
Australian Journal Dermatology
Case report
1
Diabetic
Granulation of deep ulcer
Diamond E et al
Journal American Podiatry Assoc
Case series
11
Mixed
100% healing
Olejniezak S
Medical Times
Meta Analysis Self Control
174
Mixed
Very Effective/ Favorable Results
Fischer BH
Journal Dermatological Surgery
Case series
30
Mixed
Overall positive results
Fischer BH
Lancet
Case series
52
Mixed
Positive results